Becoming invisible to Mosquitoes…

Mosquitoes are not just a summer annoyance; they are responsible for 700,000 deaths per year from deadly diseases they carry. What if mosquitos could not see their human hosts? Mosquitos are attracted to dark colors and humans register as dark regardless of what color clothing they are wearing. Researchers focused on a particular species called Aedes aegypi that use many senses including sight when they target a victim. By using CRISPER, researchers were able to target the part of their DNA that is drawn to dark.  Elimination of 2 specific proteins which are light-sensing receptors in the eyes, the mosquitos flew aimlessly even in the presence of a dark test circle which previously they were drawn to. The study was conducted at the University of California, Santa Barbara by Craig Montell a neurobiologist. This would mean control of these pests in an eco-friendly manner. These mutated mosquitos have not yet been released into the public, but can you imagine being invisible to mosquitos.

 

https://labs.mcdb.ucsb.edu/montell/craig/research/controlling-mosquito-disease-vectors-and-how-they-sense-people

New hope for Sickle Cell Anemia…

Red blood cells are round, flexible and carry oxygen throughout our bodies. Children and adults with Sickle cell disease have red blood cells in the shape of a crescent moon. These cells become sticky and block blood flow which can in turn cause infection and organ damage. This is caused by a defect in the gene that tells the body to make the iron rich compound in red blood cells (hemoglobin). The disease affects mostly African Americans and Latino families. Complications can range from anemia to infections to vision problems. In the past the treatment involved hydroxyurea (cancer drug) with bad side effects or bone marrow transplants. The FDA has just approved 2 drugs Oxbryta and Adakveo. These drugs can prevent hemoglobin in RBC from sticking together and from forming crescent shapes. In a study of 274 participants ages 12 to 65 there was a 72 to 89% decrease in anemia caused by Sickle Cell Disease. What is interesting about having the disease is that those individuals are less susceptible to being infected with malaria. Their molecular machinery for cleaning dead cells also prevents the malarial parasite from infecting them.

 

https://www.mayoclinic.org/diseases-conditions/sickle-cell-anemia/symptoms-causes/syc-20355876

https://www.google.com/search?q=oxbryta+approval&rlz=1C5CHFA_enUS892US892&oq=Oxbryta&aqs=chrome.2.69i57j0i512l9.5942j0j15&sourceid=chrome&ie=UTF-8

Metabolism and Assumptions:

We have all been told that after 20 years of age your metabolism starts to slow down, and you eventually gain weight. That men have a faster metabolism then women. That women have a harder time losing weight as opposed to men especially after menopause. Now after a new publication in “Science” these assumptions seem a little misguided. Data from 6,500 people ranging from 8 days to 95 years of age, allowed researchers to divide a lifetime into 4 distinct periods of metabolism. The study involved 80 co-authors who shared data along with information from 6 labs using data from the past 40 years. Calories were measured by what is considered the “Gold Standard”. This measures the number of calories burned by tracking the amount of carbon dioxide expelled after daily activities. All factors were taken into consideration- height, weight, percentage of body fat. 1) Infancy -metabolic rate is 50% higher than adults, 2) Age 1 to 20 metabolism slows about 3% a year, 3) 20 to 60 it holds steady, 4) after 60 declines about 0.7% per year. They found no difference between men and women. Although the metabolic rate of individuals varies, the general pattern holds true for life. The results dispute the notion that there is a constant rate of expenditure per pound. Metabolic rate is shown in these studies to be dependent on age.

 

https://www.sciencedaily.com/releases/2021/08/210812145028.htm

Drops the New Eyeglasses…

If you have difficulty reading up close you may not need to run for your glasses. As many as 128 million people have difficulty with age-related near vision. Vuity is a new eye drop which was approved By the FDA in October will be available this week. about to be given the okay. It will enable a person to see up close without affection distant vision. Presbyopia enables one to  focus on near objects in which the eye lens must change shape. This ability diminishes as we age. Vuity constricts the pupil, restricts peripheral light creating a pin hole effect. The active ingredient is pilocarpine which has been used for decades to treat glaucoma. In test trials Vuity improved near vision from 6 to 10 hours with just one drop in each eye. Its use is not to replace reading glasses but to limit the time you may need them. However, the cost is $80 for a 30-day supply and is not covered by insurance.

 

https://www.today.com/health/health/vuity-eyedrops-fda-approved-replace-reading-glasses-rcna10140